Notícies http://www.imim.cat/noticies Programa de recerca: Informàtica biomèdica Decryption of a molecular code that regulates the behavior of the cells http://www.imim.cat/noticies/view.php?ID=337 <p>The research group of <a href="https://www.imim.cat/programesrecerca/informaticabiomedica/en_farmacsproteinesg.html">GPCR Drug Discovery</a> at the Hospital del Mar Medical Research Institute (IMIM), in collaboration with the Indian Institute of Technology in Kanpur, has deciphered <strong>how nature adjusts the response of the human cell to abundant extracellular stimuli</strong> (e.g., smell, taste, light, hormones, etc.).</p> <p>When a cell receives an extracellular stimulus, it initiates a signaling process that can result in major physiological changes. This process is mediated by cell membrane proteins such as G protein coupled receptors (GPCRs). Depending on the stimulus, those receptors regulate cell activity through different molecular mechanisms.&nbsp;</p> <p>Extracellular stimulation of GPCRs leads to its activation and subsequently to the phosphorylation of its long intracellular tail. Interestingly, there are multiple phosphorylation patterns of the receptor tail - each of them linked to a specific signaling response. The phosphorylation code is read by intracellular proteins known as <strong>&beta;-arrestins</strong>. In response, they typically silence the receptor and modulate intracellular kinases, which have a global impact on cell behaviour related to gene expression, cell survival and cell death. &quot;<em><strong>Until now, the phosphorylation code and the involvement of arrestins in deciphering it has been an open question</strong></em>&quot; explains Dr. Selent. &quot;<em>We have discovered the underlying molecular mechanism of how arrestin reads and translates a specific phosphorylation pattern into a cellular response</em>&quot; she adds.</p> 15/09/2020