06/03/2018 - Press release
The Evolutionary Genomics research group at the IMIM, led by Mar Albà, has just published an article in the journal Molecular Ecology providing the results of a study that has identified which genes participate (change their expression) in the hibernation state of hairy-eared dwarf lemurs, which belong to the only group of primates that has the ability to hibernate. These small mammals store fats in their tails, allowing them to survive the months of shortage, and which they use as fuel during hibernation. Hibernation is a response to the lack of resources we normally associate with winter, but which can occur in other conditions of scarcity, such as in desert areas or, for example, during the dry season in Madagascar. “The genes involved in hibernation are present in almost all mammals, including humans. It is a question of when and how they are expressed that makes the phenomenon of hibernation possible. As they are primates, lemur genes are relatively similar to those in humans, so it is even more interesting to study this species”, explains José Luis Villanueva-Cañas, a researcher from the IMIM's Evolutionary Genomics group.
Més informació "First genetic study of primate hibernation in their natural environment"
23/01/2018 - Press release
The director of the Epidemiology and Public Health programme at the Hospital del Mar Medical Research Institute (IMIM) and CIBER Epidemiology and Public Health (CIBERESP) researcher, Jordi Alonso, was commissioned by the World Mental Health to lead an international study into the adequacy of anxiety disorder treatment across the globe. The results, from a sample of more than 51,500 individuals from 21 different countries, reveals that 10% of people suffer anxiety. Of these, only 27.6% have received some type of treatment, and this was considered appropriate in only 9.8% of the cases. It is the first time a study has described the treatment gap in anxiety disorders at an international level. "It is estimated that anxiety disorders affect 10% of the global population. These are pathologies that tend to be chronic, comorbid, and associated with a significant disability. If we add to this the fact that in 2010 they cost a group of 30 European Union countries €74,400 million, it is clear that this is an important public health problem", explains Jordi Alonso.
16/01/2018 - Press release
Being overweight or obese exponentially increases the risk of suffering heart disease or cancer. This is the conclusion of the FRESCO (Spanish Risk Function of Coronary and Other Events) study, led by researchers from the Hospital del Mar Medical Research Institute (IMIM) and doctors from Hospital del Mar, who analysed the follow up of 54,446 people from 7 autonomic communities over a ten-year period. The work involved various research groups from Barcelona, Girona, Reus, Palma de Mallorca, Zaragoza, Murcia, Pamplona, Seville, and Talavera de la Reina. The results of the study are clear. The obesity epidemic has a greater impact on women. In fact, women are 5 five times more likely to suffer a cardiovascular disease, and have 12 times greater risk of developing cancer than those of normal weight, Being overweight, even if this does not reach obesity levels, still involves twice the risk of heart disease and four times the risk of cancer.
Més informació "Obesity and overweight multiply the risk of suffering cancer and heart disease"
15-01-2018 - General information
The Food and Drug Administration's Center for Drug Evaluation and Research (FDA/CDER) and Chemotargets will work together under a 5-year Research Collaboration Agreement (RCA). The primary objective of the research agreement will be to assess the utility and performance of the Chemotargets CLARITY® intelligence & discovery platform to predict on-target and off-target activities using known pharmacology and safety data from experimental studies of small molecular entities. Evaluating in silico models for broad pharmacological profiling is of interest to CDER to predict potential adverse events of drugs in development. Additionally, insight into a chemical’s molecular target profile can help predict abuse and addiction potential, which may reduce risks associated with exposure to these substances.
18/12/2017 - Institutional news
Gasol Foundation, set up by NBA players Pau and Marc Gasol, and the Hospital del Mar Medical Research Institute (IMIM) have signed an agreement to develop joint research projects. The aim of this accord is to establish a collaboration framework between the organisations with regard to biotech research and development in the field of childhood obesity. This will allow them to work together to gain competitive funding and publicise the results of their joint projects. The agreement will promote the cross-training of staff from the two entities, and the IMIM team will provide methodological support in the design and development of the Gasol Foundation's public health interventions, as well as in the analysis and dissemination of the data they obtain. A task that will be carried out by the IMIM's Cardiovascular Risk and Nutrition research group.
04/12/2017 - Press release
What distinguishes Homo sapiens from other living beings? And the group of mammals? What makes them different? These are the questions that researchers from the Hospital del Mar Medical Research Institute (IMIM) have been trying to answer, together with the Department of Experimental and Health Sciences at the Pompeu Fabra University (UPF). To do this, they analysed the already-sequenced genomes of 68 mammals and identified 6,000 families of genes that are only found in these animals. These are genes with no homologues outside mammals, in other words, they are not present in other hairless species. In humans, it is estimated that they represent 2.5% of the genes that code for proteins. The work was led by Dr. José Luis Villanueva-Cañas, a member of the IMIM's Evolutionary Genomics research group, and currently a researcher at the Evolutionary Biology Institute (UPF-CSIC), and Dr. Mar Albà, an ICREA researcher at both the IMIM and the Biomedical Informatics Research Programme (GRIB). The study also involved Dr. David Andreu's group from the UPF's Department of Experimental and Health Sciences. It has been published in the journal Genome Biology and Evolution.
Més informació "Genes identified that distinguish mammals from other animals"
15/11/2017 - General information
Each November, the Movember Foundation encourages men from all over the world to grow a moustache to raise awareness and funds for men's health research. The Healthcare Research Group at the Hospital del Mar Medical Research Institute (IMIM) is the Spanish coordinator for an international study funded by this foundation, involving more than 5,000 patients from twelve different countries. The study, entitled "Prostate Cancer Outcomes - Compare and Reduce Variation" (PCO-CRV for short), focuses on men diagnosed with localised prostate cancer and has a global allocation of 4.6 million euros that Movember contributes, raised by crowdfunding campaigns around the world that are especially active during the month of November.
Més informació "Movember: researching how to improve quality of life after prostate cancer"
03/11/2017 - Press release
Dr. Joaquim Bellmunt, director of the Hospital del Mar Medical Research Institute (IMIM) and Associate Professor at the University of Harvard, at Dana Farber Cancer Institute in Boston, is one of the first authors of a new international study that has mapped genome of bladder cancer. As part of the TCGA project (The Cancer Genome Atlas), the researchers have reported their final analysis of 412 tumour samples, providing the most accurate genetic description to date of this type of cancer. This will enable the analysis of new personalised treatment hypotheses for this disease. The study was published in the journal Cell. Dr. Bellmunt has stated that thanks to this work, we now "have a much broader perspective on the different varieties of urinary bladder cancer and its genetic alterations". Even so, the head of the IMIM stresses that "it is necessary to continue researching the best treatments and confirm hypothesised new treatment methods."
The Hospital del Mar Medical Research Institute (IMIM) and the Pompeu Fabra University (UPF) have just published a comment in the prestigious journal Nature Reviews Drug Discovery where they explain the excellent results from eTOX, a project that has facilitated a new model for collaboration among pharmaceutical companies, as well as between these and academia, where data and knowledge are shared for the purposes of improving the toxicological evaluation of drugs. Apart from the results obtained, which are extremely valuable, the project is a model of Open Innovation, where various public and private stakeholders join forces and actively collaborate. In addition, it has confirmed the enormous value of the data obtained in the regulatory studies conducted by the pharmaceutical industry, and has verified the fact that exploiting these requires a significant effort in terms of extraction, standardisation, and integration.
Més informació "Open innovation improving drug safety evaluation"
13/09/2017 - Press release
The five-year project, Enhancing Translational Safety Assessment through Integrative Knowledge Management (eTRANSAFE), aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process and is funded by the Innovative Medicines Initiative 2 Joint Undertaking (IMI 2) together with the pharmaceutical industry. The eTRANSAFE consortium is a private and public partnership of 8 academic institutions, 6 SMEs and 12 pharmaceutical companies, and is coordinated by the Institut Hospital del Mar d'Investigacions Mèdiques (IMIM) and led by the pharmaceutical company Novartis and Bayer AG. The eTRANSAFE project aims at improving the safety assessment across the drug discovery and development process by applying bioinformatics approaches to shared preclinical and clinical data to systematically analyse the translatability of effects. Thus, enabling the optimisation of resources and the development of safer medicines.
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