MyPeBS (My Personal Breast Screening) is an international, randomised, open-label, multicentre study evaluating the effectiveness of a breast cancer screening strategy based on each woman's individual risk compared to current national screening strategies. It involves 6 countries and is one of the largest in the world.

The women will undergo a differential screening strategy over a 4-year period and then take a mammogram at the end of the study, after which they will be reincorporated into routine screening programmes. The primary endpoint of the study will be measured at the end of the four-year intervention.

In addition, follow-up data will be collected for 15 years from the start of the study to assess long-term cumulative breast cancer incidence and breast cancer-specific survival.

Study participants will be asked to complete a questionnaire and will then be randomly assigned (by a computer) into one of two groups:

Standard group: The participants will receive the breast cancer screening strategy in line with national guidelines: one mammogram every 2 years between the ages of 50 and 69 years.

Risk-based group: The participants will undergo an early detection strategy according to a personalised schedule based on their estimated 5-year risk of developing breast cancer: one mammogram every 1-4 years according to risk, with or without ultrasound depending on breast density. Risk is calculated by collecting personal data from the woman and taking a saliva sample to obtain genetic information

• MyPeBS Project website