Agenda

27/09/2017

Wilms' Tumor-1 in kidney development and disease

Auditori del PRBB a les 10:00h

Sessió científica organitzada per CERCA, CRG i IMIM.

Abstract

The Wilms’ Tumor-1 (WT1) gene is essential for kidney development. We have defined WT1 as a master transcriptional regulator in kidney progenitor cells. In mature kidneys, WT1 regulates the expression of genes in podocytes essential for maintaining glomerular filtration. During glomerular injury, decreased expression of WT1 in podocytes leads to loss of the glomerular filtration barrier.

Jordan A. Kreidberg

Professor, Harvard Medical School; Faculty Director of the Office of Fellowship Training and Director of Development and Stem Cell Research, Division of Nephrology, Boston Children's Hospital. Principal member of the Harvard Stem Cell Institute.

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